東京大学物性研究所・井上研究室

研究業績

原著論文

  1. Infrared spectroscopic analysis on structural changes around the protonated Schiff base upon retinal isomerization in light-driven sodium pump KR2
    Sahoko Tomida, Shota Ito, Tomoya Mato, Yuji Furutani, Keiichi Inoue, Hideki Kandori*. (2020) Biochimica et Biophysica Acta (BBA) - Bioenergetics, in press
    doi: 10.1016/j.bbabio.2020.148190
  2. Allosteric Communication to the Retinal Chromophore upon Ion Binding in a Light-driven Sodium Ion Pumping Rhodopsin
    Akihiro Otomo, Misao Mizuno, Keiichi Inoue, Hideki Kandori, Yasuhisa Mizutani*. (2020) Biochemistry, 59, issue 4, pp 520-529
    doi: 10.1021/acs.biochem.9b01062
  3. Crystal Structure of Heliorhodopsin
    Wataru Shihoya, Keiichi Inoue, Manish Singh, Masae Konno, Shoko Hososhima, Keitaro Yamashita, Kento Ikeda, Akimitsu Higuchi, Tamaki Izume, Sae Okazaki, Masanori Hashimoto, Ritsu Mizutori, Sahoko Tomida, Yumeka Yamauchi, Rei Abe-Yoshizumi, Kota Katayama, Satoshi P. Tsunoda, Mikihiro Shibata, Yuji Furutani, Alina Pushkarev, Oded Béjà, Takayuki Uchihashi, Hideki Kandori*, Osamu Nureki*. (2019) Nature, 574, issue 7776, pp 132-136
    doi: 10.1038/s41586-019-1604-6
  4. Unique Photochemistry Observed in a New Microbial Rhodopsin
    Chihiro Kataoka, Keiichi Inoue, Kota Katayama, Oded Béjà, Hideki Kandori*. (2019) The Journal of Physical Chemistry Letters, 10, pp 5117-5121
    doi: 10.1021/acs.jpclett.9b01957
  5. X-ray Crystallographic Structure and Oligomerization of Gloeobacter Rhodopsin
    Takefumi Morizumi†, Wei-Lin Ou†, Ned Van Eps, Keiichi Inoue, Hideki Kandori, Leonid S. Brown, Oliver P. Ernst*. (2019) Scientific Reports, 9, Article number: 11283
    doi: 10.1038/s41598-019-47445-5
  6. Engineered Functional Recovery of Microbial Rhodopsin without Retinal-Binding Lysine
    Yumeka Yamauchi, Masae Konno, Daichi Yamada, Kei Yura, Keiichi Inoue, Oded Béjà, Hideki Kandori*. (2019) Photochemistry and Photobiology, 95, pp 1116-1121
    doi: 10.1111/php.13114
  7. Red-shifting Mutation of Light-driven Sodium Pump Rhodopsin
    Keiichi Inoue, María del Carmen Marín, Sahoko Tomida, Ryoko Nakamura, Yuta Nakajima, Massimo Olivucci, Hideki Kandori*. (2019) Nature Communications, 10, Article number: 1993
    doi: 10.1038/s41467-019-10000-x
  8. Casting Light on Asgardarchaeota Metabolism in a Sunlit Microoxic Niche
    Paul-Adrian Bulzu†, Adrian-Ştefan Andrei†, Michaela M. Salcher, Maliheh Mehrshad, Keiichi Inoue, Hideki Kandori, Oded Béjà, Rohit Ghai*, Horia L. Banciu. (2019) Nature Microbiology, 4, issue 7, pp 1129-1137
    doi: 10.1038/s41564-019-0404-y (†: Equally contributed)
  9. Ultrafast Dynamics of Heliorhodopsins
    Shinya Tahara, Manish Singh, Hikaru Kuramochi, Wataru Shihoya, Keiichi Inoue, Osamu Nureki, Oded Béjà, Yasuhisa Mizutani, Hideki Kandori, Tahei Tahara*. (2019) The Journal of Physical Chemistry B, 123, issue 11, pp 2507-2512
    doi: 10.1021/acs.jpcb.9b00887
  10. Heliorhodopsins are Absent in Diderm (Gram-negative) Bacteria: Some Thoughts and Possible Implications for Activity
    José Flores-Uribe†, Gur Hevroni†, Rohit Ghai, Alina Pushkarev, Keiichi Inoue, Hideki Kandori, Oded Béjà*. (2019) Environmental Microbiology Reports, 11, issue 3, pp 419-424
    doi: 10.1111/1758-2229.12730 (†: Equally contributed)
  11. Resonance Raman Investigation of the Chromophore Structure of Heliorhodopsins
    Akihiro Otomo, Misao Mizuno, Manish Singh, Wataru Shihoya, Keiichi Inoue, Osamu Nureki, Oded Béjà, Hideki Kandori, Yasuhisa Mizutani*. (2018) The Journal of Physical Chemistry Letters, 9, issue 22, pp 6431-6436
    doi: 10.1021/acs.jpclett.8b02741
  12. Understanding Colour Tuning Rules and Predicting Absorption Wavelengths of Microbial Rhodopsins by Data-Driven Machine-Learning Approach
    Masayuki Karasuyama†, Keiichi Inoue†, Ryoko Nakamura, Hideki Kandori*, Ichiro Takeuchi*. (2018) Scientific Reports, 8, Article number:15580
    doi: 10.1038/s41598-018-33984-w (†: Equally contributed)

解説記事

  1. 光で細胞を制御する―多様な微生物型ロドプシンとオプトジェネティクス―
    井上 圭一 (2020) 日本光学会誌 光学「光で細胞のはたらきを見る・操る」, 第49巻, 第1号, pp 2-7
  2. ハエトリグモにおける視覚機能とオプシンの吸収波長特性の関係
    永田 崇、寺北 明久 (2019) 日本比較生理生化学会誌 比較生理生化学 総説, 第36巻, 第3号, pp 175-181
  3. オプトジェネティクス触覚モデルによる異種感覚間可塑性の定量的解析
    阿部 健太、八尾 寛 (2019) 日本生物物理学会誌 生物物理誌「トピックス」, 第59巻, 第6号, pp 317-319
  4. 微生物型ロドプシンのもたらす新たな生物と光の関係とその応用
    井上 圭一 (2019) 生物工学会誌 生物工学「バイオミディア」, 第97巻, 第10号, pp 616
  5. 第3のロドプシン:ヘリオロドプシンの発見
    井上 圭一, 神取 秀樹 (2019) バイオサイエンスとインダストリー (B&I), 第77巻, 第1号, pp 42-43

受賞

  1. 第21回サー・マーティン・ウッド賞
    「光受容型膜タンパク質微生物型ロドプシンの生体機能発現メカニズム研究
    (The study on the mechanism of biological function of photoreceptive membrane protein, microbial rhodopsin)」
    井上 圭一 2019年11月23日
  2. 第4回日本光生物学協会奨励賞
    「微生物型ロドプシンの機能・構造・メカニズム研究と新奇分子デザイン」
    井上 圭一 2018年8月9日