Inoue Laboratory, ISSP, Univ. Tokyo


Keiichi Inoue
Associate professor (CV)
  • 2002: B.S. Department of chemistry, Kobe university
  • 2004: M.S. Department of chemistry, Kyoto university
  • 2006-2007: JSPS Research fellowship for young scientists (DC2)
  • 2007: Ph. D. (Science) Department of chemistry, Kyoto university
  • 2007-2009: Project Assistant professor, Chemical resources laboratory, Tokyo institute of technology
  • 2009-2016: Assistant professor, Department of frontier materials, Nagoya institute of technology
  • 2012-2015: JST PRESTO researcher (Research area: Design and control of cellular functions)
  • 2015-2019: JST PRESTO researcher (Research area: FRONTIER)
  • 2016-2018: Associate professor, Department of life science and applied chemistry, Nagoya institute of technology
  • 2018-present: Institute for Solid state physics, Tokyo university
Blood type: A
Hobby: Reading books, Watching sports, Rhodopsin exploration
Comment: Let's enjoy your science!
E-mail: inoue*
(Exchange "*" to "@")
Research theme
Physicochemical study on the molecular mechanism of microbial rhodopsins and other photo-receptive proteins

Original papers
  1. Excitonic coupling effect on the circular dichroism spectrum of sodium-pumping rhodopsin KR2
    Kazuhiro J. Fujimoto*, Keiichi Inoue. (2020) Journal of Chemical Physics, 153, Article number: 045101
    doi: 10.1063/5.0013642
  2. Gate-keeper of ion transport ―a highly conserved helix-3 tryptophan in a channelrhodopsin chimera, C1C2/ChRWR
    Yujiro Nagasaka†, Shoko Hososhima†, Naoko Kubo, Takashi Nagata, Hideki Kandori, Keiichi Inoue and Hiromu Yawo*. (2020) Biophysics and physicobiology (BPPB), 17, pp 59-70
    doi: 10.2142/biophysico.BSJ-2020007 (†: Equally contributed)
  3. Schizorhodopsins: A family of Rhodopsins from Asgard Archaea that Function as Light-driven Inward H+ Pumps
    Keiichi Inoue*, Satoshi P. Tsunoda, Manish Singh, Sahoko Tomida, Shoko Hososhima, Masae Konno, Ryoko Nakamura, Hiroki Watanabe, Paul-Adrian Bulzu, Horia L. Banciu, Adrian-Ştefan Andrei, Takayuki Uchihashi, Rohit Ghai, Oded Béjà, Hideki Kandori*. (2020) Science Advances, 6, No. 15, Article number: eaaz2441
    doi: 10.1126/sciadv.aaz2441
  4. Infrared Spectroscopic Analysis on Structural Changes around the Protonated Schiff Base upon Retinal Isomerization in Light-driven Sodium Pump KR2
    Sahoko Tomida, Shota Ito, Tomoya Mato, Yuji Furutani, Keiichi Inoue, Hideki Kandori*. (2020) Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1861, issue 7, Article number: 148190
    doi: 10.1016/j.bbabio.2020.148190
  5. Allosteric Communication to the Retinal Chromophore upon Ion Binding in a Light-driven Sodium Ion Pumping Rhodopsin
    Akihiro Otomo, Misao Mizuno, Keiichi Inoue, Hideki Kandori, Yasuhisa Mizutani*. (2019) Biochemistry, 59, issue 4, pp 520-529
    doi: 10.1021/acs.biochem.9b01062
  6. Crystal Structure of Heliorhodopsin
    Wataru Shihoya, Keiichi Inoue, Manish Singh, Masae Konno, Shoko Hososhima, Keitaro Yamashita, Kento Ikeda, Akimitsu Higuchi, Tamaki Izume, Sae Okazaki, Masanori Hashimoto, Ritsu Mizutori, Sahoko Tomida, Yumeka Yamauchi, Rei Abe-Yoshizumi, Kota Katayama, Satoshi P. Tsunoda, Mikihiro Shibata, Yuji Furutani, Alina Pushkarev, Oded Béjà, Takayuki Uchihashi, Hideki Kandori*, Osamu Nureki*. (2019) Nature, 574, issue 7776, pp 132-136
    doi: 10.1038/s41586-019-1604-6
  7. Unique Photochemistry Observed in a New Microbial Rhodopsin
    Chihiro Kataoka, Keiichi Inoue, Kota Katayama, Oded Béjà, Hideki Kandori*. (2019) The Journal of Physical Chemistry Letters, 10, pp 5117-5121
    doi: 10.1021/acs.jpclett.9b01957
  8. X-ray Crystallographic Structure and Oligomerization of Gloeobacter Rhodopsin
    Takefumi Morizumi†, Wei-Lin Ou†, Ned Van Eps, Keiichi Inoue, Hideki Kandori, Leonid S. Brown, Oliver P. Ernst*. (2019) Scientific Reports, 9, Article number: 11283
    doi: 10.1038/s41598-019-47445-5
  9. Engineered Functional Recovery of Microbial Rhodopsin without Retinal-Binding Lysine
    Yumeka Yamauchi, Masae Konno, Daichi Yamada, Kei Yura, Keiichi Inoue, Oded Béjà, Hideki Kandori*. (2019) Photochemistry and Photobiology, 95, pp 1116-1121
    doi: 10.1111/php.13114
  10. Red-shifting Mutation of Light-driven Sodium Pump Rhodopsin
    Keiichi Inoue, María del Carmen Marín, Sahoko Tomida, Ryoko Nakamura, Yuta Nakajima, Massimo Olivucci, Hideki Kandori*. (2019) Nature Communications, 10, Article number: 1993
    doi: 10.1038/s41467-019-10000-x
  11. Casting Light on Asgardarchaeota Metabolism in a Sunlit Microoxic Niche
    Paul-Adrian Bulzu†, Adrian-Ştefan Andrei†, Michaela M. Salcher, Maliheh Mehrshad, Keiichi Inoue, Hideki Kandori, Oded Béjà, Rohit Ghai*, Horia L. Banciu. (2019) Nature Microbiology, 4, issue 7, pp 1129-1137
    doi: 10.1038/s41564-019-0404-y (†: Equally contributed)
  12. Ultrafast Dynamics of Heliorhodopsins
    Shinya Tahara, Manish Singh, Hikaru Kuramochi, Wataru Shihoya, Keiichi Inoue, Osamu Nureki, Oded Béjà, Yasuhisa Mizutani, Hideki Kandori, Tahei Tahara*. (2019) The Journal of Physical Chemistry B, 123, issue 11, pp 2507-2512
    doi: 10.1021/acs.jpcb.9b00887
  13. Heliorhodopsins are Absent in Diderm (Gram-negative) Bacteria: Some Thoughts and Possible Implications for Activity
    José Flores-Uribe†, Gur Hevroni†, Rohit Ghai, Alina Pushkarev, Keiichi Inoue, Hideki Kandori, Oded Béjà*. (2019) Environmental Microbiology Reports, 11, issue 3, pp 419-424
    doi: 10.1111/1758-2229.12730 (†: Equally contributed)
  14. Resonance Raman Investigation of the Chromophore Structure of Heliorhodopsins
    Akihiro Otomo, Misao Mizuno, Manish Singh, Wataru Shihoya, Keiichi Inoue, Osamu Nureki, Oded Béjà, Hideki Kandori, Yasuhisa Mizutani*. (2018) The Journal of Physical Chemistry Letters, 9, issue 22, pp 6431-6436
    doi: 10.1021/acs.jpclett.8b02741
  15. Understanding Colour Tuning Rules and Predicting Absorption Wavelengths of Microbial Rhodopsins by Data-Driven Machine-Learning Approach
    Masayuki Karasuyama†, Keiichi Inoue†, Ryoko Nakamura, Hideki Kandori*, Ichiro Takeuchi*. (2018) Scientific Reports, 8, Article number:15580
    doi: 10.1038/s41598-018-33984-w (†: Equally contributed)
Review papers

  1. 2019 Sir Martin Wood Prize
    "The study on the mechanism of biological function of photoreceptive membrane protein, microbial rhodopsin"
    Keiichi Inoue, November 23, 2019