Inoue Laboratory, ISSP, Univ. Tokyo

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  1. April 1, 2024 Member page was updated. Yoshitaka Kato, Zhou Qianfan, and Hiroto Takahashi joined to our lab.
  2. March 31, 2024 Member page was updated. Keisei Shibata, Yuma Kawasaki, and Yifan Liu finished the reasearch in our lab.
  3. March 8, 2024 Publication page was updated. "Chromophore–Protein Interactions Affecting the Polyene Twist and π–π* Energy Gap of the Retinal Chromophore in Schizorhodopsins" was published in The Journal of Physical Chemistry B.
  4. January 11, 2024 Publication page was updated. "Cis–Trans Reisomerization Preceding Reprotonation of the Retinal Chromophore is Common to the Schizorhodopsin Family: A Simple and Rational Mechanism for Inward Proton Pumping" was published in The Journal of Physical Chemistry B.
  5. October 27, 2023 Publication page was updated. "Multiple Roles of a Conserved Glutamate Residue for Unique Biophysical Properties in a New Group of Microbial Rhodopsins Homologous to TAT Rhodopsin" was published in Journal of Molecular Biology.
  6. October 19, 2023 Publication page was updated. "Iron-limitation light switch" was published in Nature Microbiology.
  7. October 19, 2023 Publication page was updated. "Photochemistry of the Retinal Chromophore in Microbial Rhodopsins" was published in The Journal of Physical Chemistry B.
  8. October 1, 2023 Member page was updated. Xiang Xin joined to our lab.
  9. September 22, 2023 Publication page was updated. Keiichi Inoue received the "International Union of Photobiology (IUPB), Finsen Lecturer"
  10. August 31, 2023 Publication page was updated. "Structural Basis for Color Tuning and Ion Selectivity in Potassium-Selective Channelrhodopsins" was published in Cell
  11. August 2, 2023 Publication page was updated. "Effects of the Unique Chromophore–Protein Interactions on the Primary Photoreaction of Schizorhodopsin" was published in The Journal of Physical Chemistry Letters
  12. May 2, 2023 Publication page was updated. "Twisting and Protonation of Retinal Chromophore Regulate Channel Gating of Channelrhodopsin C1C2" was published in Journal of the American Chemical Society
  13. April 21, 2023 Publication page was updated. "Converting a Natural Light-driven Outward Proton Pump Rhodopsin into an Artificial Inward Proton Pump" was published in Journal of the American Chemical Society
  14. April 19, 2023 Publication page was updated. "Time-Resolved Detection of Light-induced Conformational Changes of Heliorhodopsin" was published in Physical Chemistry Chemical Physics
  15. April 14, 2023 Publication page was updated. "Reversible Photoreaction of a Retinal Photoisomerase, Retinal G-Protein-Coupled Receptor RGR" was published in Biochemistry
  16. April 1, 2023 Member page was updated. Keisei Shibata joined to our lab.
  17. March 31, 2023 Member page was updated. Hanae Ara finished the reasearch and Tomohiro Ishizuka graduated from master course in our lab.
  18. March 31, 2023 Publication page was updated. "Difference FTIR Spectroscopy of Jumping Spider Rhodopsin-1 at 77 K" was published in Biochemistry
  19. March 8, 2023 Publication page was updated. "Biophysical Characterization of Microbial Rhodopsins with DSE Motif" was published in Biophysics and Physicobiology
  20. March 8, 2023 Publication page was updated. "Biophysical Characterization of Microbial Rhodopsins with DSE Motif" was published in Biophysics and Physicobiology
  21. March 5, 2023 Publication page was updated. "Characterization of Retinal Chromophore and Protonated Schiff Base in Thermoplasmatales Archaeon Heliorhodopsin Using Solid-State NMR Spectroscopy" was published in Biophysical Chemistry
  22. March 2, 2023 Publication page was updated. "Phototrophy by Antenna-Containing Rhodopsin Pumps in Aquatic Environments" was published in Nature
  23. February 26, 2023 Publication page was updated. "Protein Dynamics of a Light-Driven Na+ Pump Rhodopsin Probed Using a Tryptophan Residue Near the Retinal Chromophore" was published in Biophysics and Physicobiology
  24. December 6, 2022 Member page was updated. María del Carmen Marín Pérez finished the research in our lab.
  25. November 1, 2022 Member page was updated. Yifan Liu joined to our lab.
  26. October 1, 2022 Member page was updated. Chunyangguang Li joined to our lab.
  27. September 30, 2022 Member page was updated. Chenxiang Zhao graduated from master course in our lab.
  28. September 1, 2022 Member page was updated. Miki Saito joined to our lab.
  29. August 2, 2022 Publication page was updated. "Kinetic study on the molecular mechanism of light-driven inward proton transport by schizorhodopsins" was published in Biochim. Biophys. Acta Biomembr.
  30. June 17, 2022 Publication page was updated. "Rhodopsin-bestrophin Fusion Proteins from Unicellular Algae form Gigantic Pentameric Ion Channels" was published in Nat. Struct. Mol. Biol.
  31. June 1, 2022 Member page was updated. Mariko Suzuki joined to our lab.
  32. May 31, 2022 Member page was updated. Motoko Yoshizawa finished business activity in our lab.
  33. April 20, 2022 Publication page was updated. "Saccharibacteria Harness Light Energy Using Type-1 Rhodopsins That May Rely on Retinal Sourced from Microbial Hosts" was published in ISME J.
  34. April 1, 2022 Member page was updated. Zikun Lyu joined to our lab.
  35. March 31, 2022 Member page was updated. Hiromu Yawo and Reza Bagherzadeh finished the reasearch and Naoya Morimoto graduated from master course in our lab.
  36. February 11, 2022 Publication page was updated. "Structural Characterization of Proton-pumping Rhodopsin Lacking a Cytoplasmic Proton Donor Residue by X-ray Crystallography" was published in Journal of Biological Chemistry.
  37. February 3, 2022 Publication page was updated. "Structural Basis for Channel Conduction in the Pump-like Channelrhodopsin ChRmine" was published in Cell.
  38. January 5, 2022 Publication page was updated. "Diverse Heliorhodopsins Detected via Functional Metagenomics in Freshwater Actinobacteria, Chloroflexi and Archaea" was published in Environmental Microbiology.
  39. November 27, 2021 Publication page was updated. "Heliorhodopsin Evolution is Driven by Photosensory Promiscuity in Monoderms" was published in mSphere.
  40. November 25, 2021 Publication page was updated. "Rhodopsins at a glance" was published in Journal of Cell Science.
  41. October 13, 2021 Publication page was updated. "Pro219 is an electrostatic color determinant in the light-driven sodium pump KR2" was published in Communications Biology.
  42. August 4, 2021 Publication page was updated. "Microbial Rhodopsins: The Last Two Decades" was published in Annual Review of Microbiology.
  43. July 1, 2021 Publication page was updated. "Thermostable Light-Driven Inward Proton Pump Rhodopsins" was published in Chemical Physics Letters.
  44. April 7, 2021 Publication page was updated. "The Third Class of Rhodopsin: Heliorhodopsin" was published in CSJ "Chemistry and Chemical Industry: Division Topics".
  45. April 1, 2021 Publication page was updated. "Crystal Structure of Schizorhodopsin Reveals Mechanism of Inward Proton Pumping" was published in Proceedings of the National Academy of Sciences of the United States of America.
  46. April 1, 2021 Member page was updated. Shunki Takaramoto and Tomohiro Ishizuka joined to our lab.
  47. March 31, 2021 Member page was updated. Kentaro Mannen graduated from master course in our lab.
  48. March 19, 2021 Publication page was updated. "Exploration of Natural Red-shifted Rhodopsins Using a Machine Learning-based Bayesian Experimental Design" was published in Communications Biology.
  49. March 17, 2021 Publication page was updated. "TAT Rhodopsin is an Ultraviolet-Dependent Environmental pH Sensor" was published in Biochemistry.
  50. February 5, 2021 Publication page was updated. "Ion transport assay of SzRs in E. coli cells" was published in Bio-protocol.
  51. January 6, 2021 "Diversity, Mechanism, and Optogenetic Application of Light-Driven Ion Pump Rhodopsins" and "Application of Optogenetics for Muscle Cells and Stem Cells" were contributed in Optogenetics − Light-Sensing Proteins and Their Applications in Neuroscience and Beyond.
  52. November 30, 2020 Member page was updated. María del Carmen Marín Pérez joined to our lab.
  53. October 31, 2020 Publication page was updated. "Shining Light on Rhodopsin Selectivity: How Do Proteins Decide Whether to Transport H+ or Cl–?" was published in The Journal of Biological Chemistry.
  54. October 20, 2020 Publication page was updated. "Active Learning for Level Set Estimation under Input Uncertainty and Its Extensions" was published in Neural Computation.
  55. September 25, 2020 Member page was updated. Chenxiang Zhao joined to our lab.
  56. August 14, 2020 Publication page was updated. "Active Learning of Bayesian Linear Models with High-Dimensional Binary Features by Parameter Confidence-Region Estimation" was published in Neural Computation.
  57. July 23, 2020 Publication page was updated. "Excitonic coupling effect on the circular dichroism spectrum of sodium-pumping rhodopsin KR2" was published in Journal of Chemical Physics.
  58. June 9, 2020 Publication page was updated. "Gate-keeper of ion transport ―a highly conserved helix-3 tryptophan in a channelrhodopsin chimera, C1C2/ChRWR" was published in Biophysics and physicobiology (BPPB).
  59. April 17, 2020 Publication page was updated. "Optogenetic Analysis of Respiratory Neuronal Networks in The Ventral Medulla of Neonatal Rats Producing Channelrhodopsin in Phox2b-Positive Cells" was published online in Pflügers Arch, and "Physical Disuse Contributes to Widespread Chronic Mechanical Hyperalgesia, Tactile Allodynia, and Cold Allodynia through Neurogenic Inflammation and Spino-Parabrachio-Amygdaloid Pathway Activation" was published online in Pain.
  60. April 11, 2020 Publication page was updated. "Schizorhodopsins: A Family of Rhodopsins from Asgard Archaea That Function as Light-driven Inward H+ Pumps" was published in Science Advances.
  61. April 1, 2020 Member page was updated. Yuuma Kawasaki and Naoya Morimoto joined to our lab.
  62. March 18, 2020 Publication page was updated. "Infrared Spectroscopic Analysis on Structural Changes around the Protonated Schiff Base upon Retinal Isomerization in Light-driven Sodium Pump KR2" was published online in Biochimica et Biophysica Acta (BBA) - Bioenergetics.
  63. January 1, 2020 Publication page was updated. "Allosteric Communication to the Retinal Chromophore upon Ion Binding in a Light-driven Sodium Ion Pumping Rhodopsin" was published in Biochemistry.
  64. December 29, 2019 "Photos" page opened."Photos" page opened
  65. November 25, 2019 Publication page was updated. Keiichi Inoue received the "Sir Martin Wood Prize"
  66. October 15, 2019 Press Information. Our research was introduced in "Top Researchers (JPN)" in IGPI Technology.
  67. October 1, 2019 Member page was updated. Masae Konno and Reza Bagherzadeh joined to our lab.
  68. September 26, 2019 Publication page was updated. "Crystal Structure of Heliorhodopsin" was published in Nature
  69. August 22, 2019 Publication page was updated. "Unique Photochemistry Observed in a New Microbial Rhodopsin" was published in J. Phys. Chem. Lett.
  70. August 5, 2019 Publication page was updated. "X-ray Crystallographic Structure and Oligomerization of Gloeobacter Rhodopsin" was published in Sci. Rep.
  71. August 1, 2019 Member page was updated. Naoko Kubo joined to our lab.
  72. July 1, 2019 Our website opened. Our website opened.